Caffeine, exercise and genetics

by Dr. Ajmol Ali

Caffeine has for several decades been shown to provide an ergogenic effect on exercise performance when taken in the correct dosage. However, the effect of caffeine on performance varies between individuals. Several genes have been linked to caffeine metabolism; among these genes is the CYP1A2 gene which is found on the cytochrome P450. Some research suggests that ‘fast’ metabolisers of caffeine (homozygous A variant allele) may show better performance benefits relative to ‘slow’ metabolisers of caffeine (C variant allele).

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